TOTUM-854

TOTUM-854 is a **polyphenol-rich blend of six plant extracts** developed as a proprietary botanical formulation for vascular protection and the prevention or management of mild to moderate hypertension. It is not a single chemical entity but a standardised combination whose individual plant-derived compounds have been shown to impact inflammation and oxidative stress. Its mechanism of action includes: - Inhibition of angiotensin-converting enzyme 1 (ACE-1) activity, which reduces the production of angiotensin II and thus lowers vasoconstriction and blood pressure. - Reduction of oxidative stress by lowering NADPH oxidase (NOX2) mediated reactive oxygen species (ROS) production. - Reduction of inflammatory markers (IL-1β, MCP-1, and VCAM-1), which are implicated in endothelial dysfunction. TOTUM-854 shows bioactive metabolite absorption in humans and has demonstrated efficacy in rodent models and ex vivo human vascular assays. Its development is ongoing through clinical trials for **moderate hypertension** and potentially as a preventive strategy against cardiovascular disease. The developer is Valbiotis, a French nutraceutical company.[1][2][3][4][5]

Brand names

TOTUM-854TOTUM854TOTUM 854TOTUM•854

Other names

TOTUM-854TOTUM854TOTUM 854T-854T854T 854