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Tou Feng Yu Pill

Development stage
Preclinical
Administration
Oral
01

Overview

Tou Feng Yu Pill (TFY) is a **traditional Chinese herbal medicine** formulation specifically developed for the treatment of **migraine**. It consists of three herbal components: **Radix Angelicae dahuricae** (Baizhi), **Rhizome Ligustici** (Chuanxiong), and **Folium Camelliae sinensis** (green tea). The therapeutic mechanism involves multiple pathways: (1) **adjusting neurotransmitter levels** including dopamine, serotonin (5-HT), norepinephrine (NE), and neuropeptides such as calcitonin gene-related peptide (CGRP), thereby relieving neurogenic inflammation; (2) **modulating vasoactive substances** including nitric oxide (NO) and endothelin (ET), improving vasomotion and cerebral blood flow while reducing cerebrovascular resistance; and (3) **increasing pain threshold** through analgesic effects. The formulation has demonstrated efficacy in reducing pain associated with migraine through both peripheral and central nervous system mechanisms.

Brand names
Tou Feng Yu Pill
Other names
TFYTou-Feng-Yu pill
02

Targets

ET (Endothelin receptors)CGRP (Calcitonin gene-related peptide)

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