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tozinameran + riltozinameran (BioNTech SE)
- Development stage
- Phase 2
- Lead developer
- Pfizer
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**Tozinameran + riltozinameran** is the bivalent original/Omicron BA.1 formulation of the Pfizer-BioNTech COVID-19 mRNA vaccine marketed as **Comirnaty Original/Omicron BA.1**. It contains equal 15-microgram amounts of two lipid-nanoparticle-formulated nucleoside-modified mRNAs: tozinameran, encoding the ancestral SARS-CoV-2 spike protein, and riltozinameran, encoding the Omicron BA.1 spike protein. Following intramuscular administration, translated spike antigens stimulate neutralising antibody and cellular immune responses against SARS-CoV-2. It was authorized as a booster vaccine for prevention of COVID-19; later variant-updated Comirnaty formulations superseded the BA.1 product. ([ema.europa.eu](https://www.ema.europa.eu/en/documents/variation-report/comirnaty-h-c-005735-ii-0140-epar-assessment-report-variation_en.pdf))
- Brand names
- Comirnaty Original/Omicron BA.1
- Other names
- tozinameran + riltozinamerantozinameran/riltozinameran
02
Targets
80S ribosome (Ribosome and ribosomal components)
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