TP-ICG

**TP-ICG** is an investigational Trop2-targeted near-infrared-II fluorescent molecular imaging probe composed of a Trop2-targeting polypeptide linked to indocyanine green. It is designed to bind trophoblast cell surface antigen 2-expressing ovarian cancer cells and provide intraoperative fluorescence visualization of tumor margins and small abdominal metastatic lesions during cytoreductive surgery. In cell and mouse models of Trop2-positive ovarian cancer, TP-ICG showed higher tumor uptake and tumor-to-background signal than a control probe and detected metastatic lesions smaller than 1 mm. ([aacrjournals.org](https://aacrjournals.org/cancerres/article/85/8_Supplement_2/LB479/761606/Abstract-LB479-Nir-ii-fluorescence-imaging-based))

Other names

Trop2 targeting polypeptide-ICGTrop-2 targeting polypeptide-ICGTrop 2 targeting polypeptide-ICG