Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
TPA2
- Development stage
- Preclinical
- Lead developer
- Virginia Commonwealth University
- Modality
- Small Molecules
- Administration
- Intravenous, Intraosseous, Intracatheter, Catheter-directed, Intrapleural, Intraventricular
01
Overview
**TPA2** is an experimental trans-platinum(II) planar-amine anticancer complex containing an isoquinoline carrier ligand and a hydroxyacetate leaving group. It was reported by researchers at Virginia Commonwealth University as part of a trans-platinum planar amine carboxylate series. In preclinical studies, TPA2 showed greater cellular accumulation and cytotoxicity than the more inert acetate analogue TPA1, retained activity after serum pre-incubation, and demonstrated antitumor activity in a luciferase-expressing A2780 human ovarian cancer mouse model. Its precise molecular pharmacology is not fully established; it displays limited DNA binding and a cytotoxic profile distinct from cisplatin.
- Other names
- TPA2TPA-2TPA 2trans-platinum planar amine hydroxyacetate complex
Beyond the preview
Go deeper on TPA2.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on TPA2.