TPGS-modified liposomal ginger extract

TPGS-modified liposomal ginger extract is an advanced drug delivery formulation designed to overcome the low bioavailability and poor aqueous solubility of conventional ginger extract. This system utilizes liposomes—phospholipid-based vesicles—modified with D-α-tocopheryl polyethylene glycol succinate (TPGS), a water-soluble derivative of Vitamin E that enhances stability, prevents liposome aggregation, and improves intestinal absorption. The formulation encapsulates the bioactive constituents of ginger, such as gingerols and shogaols, which possess potent anti-inflammatory and antioxidant properties. Preclinical studies in models of ulcerative colitis have demonstrated that this liposomal delivery system significantly reduces mucosal damage and oxidative stress compared to standard ginger extract, suggesting its potential as a therapeutic agent for inflammatory bowel diseases.

Other names

TPGS-modified liposomes of ginger extractTPGS-ginger liposomes