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TPIP F3

Development stage: Unknown
Lead developer: Insmed
Modality: Small Molecules
Administration: Inhalation

Overview

TPIP F3 is a specific dry powder formulation of treprostinil palmitil, an investigational prodrug of the prostacyclin analogue treprostinil. Developed by Insmed Incorporated, TPIP is designed for once-daily inhalation to treat pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD). The prodrug consists of treprostinil linked by an ester bond to a 16-carbon chain, which is intended to provide a sustained-release profile within the lungs. TPIP F3 was evaluated in Phase 1 clinical trials to compare its bioavailability and safety profile against an earlier formulation (F2), aiming to optimize the delivery of treprostinil to the pulmonary vasculature while minimizing systemic side effects.

Other names: treprostinil palmitil inhalation powder formulation 3

Targets

PTGIR (Prostanoid IP Receptor)PTGER2 (Prostaglandin E2 receptor EP2)

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