Drug intelligence / Profile preview

TQB2930

Development stage
Phase 3
Lead developer
Chia Tai-Tianqing Pharmaceutical Group
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

TQB2930 is a bispecific monoclonal antibody that targets two distinct epitopes on the human epidermal growth factor receptor 2 (HER2; ErbB2), specifically binding to the same domains as trastuzumab (extracellular domain 4) and pertuzumab (extracellular domain 2)[1][3]. It is designed for immunomodulating and antineoplastic activity in HER2-positive cancers, particularly breast cancer. Clinical studies have shown that TQB2930 is well tolerated and demonstrates promising single-agent anti-tumor activity in patients with advanced or metastatic HER2-positive breast cancer who have failed standard anti-HER2 therapies[2][3][5]. The drug has been evaluated in phase 1b/II trials both as monotherapy and in combination with chemotherapy. The developer of TQB2930 is Chia Tai Tianqing Pharmaceutical Group/Nanjing Shunxin Pharmaceutical.

Other names
anti-HER2 bispecific antibody TQB2930anti-HER-2 bispecific antibody TQB2930anti-HER 2 bispecific antibody TQB2930
02

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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