Drug intelligence / Profile preview

TQB3616 + anlotinib

Development stage
Preclinical
Lead developer
Chia Tai-Tianqing Pharmaceutical Group
Modality
Small Molecules
Administration
Oral
01

Overview

A combination therapy consisting of **TQB3616** and **anlotinib**. TQB3616 is under investigation as an anti-cancer agent, most likely a small molecule targeting androgen receptor pathways (as inferred from naming conventions and context), but direct characterization in the results above is not detailed. **Anlotinib** is an oral small molecule receptor tyrosine kinase inhibitor. Anlotinib simultaneously targets VEGFR1-3 (vascular endothelial growth factor receptor), FGFR1-4 (fibroblast growth factor receptor), PDGFR-α/β (platelet-derived growth factor receptor), c-kit (stem cell factor receptor), and possibly other kinases. It exerts anti-angiogenic and anti-proliferative effects, inhibiting tumor blood vessel growth and tumor cell proliferation[1][5][7]. The combination is under development, likely for cancer indications, but specific published clinical data on "TQB3616 + anlotinib" as a pairing are currently unavailable in the above references.

02

Targets

AURKB (Aurora kinase B)CDK2 (Cyclin-dependent kinase 2)CDK4 (Cyclin-dependent kinase 4)CDK6 (Cyclin-dependent kinase 6)DDR1 (Discoidin domain receptor 1)FGFR1 (Fibroblast growth factor receptor 1)PDGFRB (Platelet-derived growth factor receptor beta)RET (Rearranged during transfection receptor tyrosine kinase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)CSF1R (Macrophage colony-stimulating factor receptor)KIT (c-KIT proto-oncogene receptor tyrosine kinase)AR (Adrenergic receptors)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)

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