Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
TQB3616 + TQB2450
- Development stage
- Preclinical
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
TQB3616 + TQB2450 is a combination therapy consisting of TQB3616, a novel CDK2/4/6 inhibitor, and TQB2450 (benmelstobart), a humanized IgG1 monoclonal antibody targeting PD-L1. TQB3616 works by inhibiting cyclin-dependent kinases 2, 4, and 6, showing enhanced tumor killing effects by promoting cell apoptosis and inducing G1 cell cycle arrest. TQB2450 targets the PD-L1 immune checkpoint, potentially enhancing anti-tumor immune responses. This combination is being investigated for potential synergistic effects in cancer treatment.
- Other names
- culmerciclib + TQB2450culmerciclib + benmelstobart
02
Targets
CD274 (Programmed cell death protein 1 ligand 1)CDK6 (Cyclin-dependent kinase 6)CDK4 (Cyclin-dependent kinase 4)CDK2 (Cyclin-dependent kinase 2)
Beyond the preview
Go deeper on TQB3616 + TQB2450.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on TQB3616 + TQB2450.