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TR1.2

Development stage: Preclinical
Lead developer: University of Nebraska Medical Center
Modality: Peptides, Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

TR1.2 is a recombinant peptide consisting of the SEA (Sea-urchin sperm protein, Enterokinase and Agrin) domain 5 of the MUC16 (CA125) glycoprotein. It is being investigated for its role in the MUC16/ERBB signaling axis in pancreatic cancer. TR1.2 binds specifically to domain 1 of the ERBB3 receptor, inducing a conformational change that maintains the receptor in a monomeric state and prevents its dimerization. This modulation of ERBB3 leads to a shift in the ERBB signaling landscape, promoting the heterodimerization of ERBB2 and EGFR and subsequently enhancing downstream oncogenic signaling via the AKT pathway. The peptide serves as a tool to understand how circulating fragments of MUC16 contribute to tumor progression and metastasis.

Other names: MUC16 SEA domain 5 peptideMUC-16 SEA domain 5 peptideMUC 16 SEA domain 5 peptide

Targets

ERBB3 (Erb-b2 receptor tyrosine kinase 3)

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