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Traditional Chinese medicine comprehensive sequential therapy is a structured therapeutic regimen developed by the Shanghai Hospital of Traditional Chinese Medicine for the treatment of adult patients with severe (Grade IV) acne vulgaris. This therapy is specifically designed for individuals presenting with the 'phlegm and blood stasis coagulation' syndrome, a Traditional Chinese Medicine (TCM) classification. The 'comprehensive sequential' approach involves a phased application of TCM interventions, which typically include oral herbal decoctions and potentially topical treatments, aimed at resolving deep-seated nodules and cysts. It is currently being evaluated in clinical trials to compare its efficacy and safety profile against standard Western medical treatments, such as isotretinoin.
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