Drug intelligence / Profile preview

traditional Chinese medicine granules for tonifying kidney and promoting blood circulation

Development stage
Preclinical
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Traditional Chinese medicine granules for tonifying kidney and promoting blood circulation (also known as Bushen Huoxue granules) is an investigational herbal formulation developed by Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. It is designed to address the traditional Chinese medicine (TCM) syndrome pattern of liver-kidney yin deficiency with blood stasis. The formulation is being evaluated in clinical trials in China, in combination with ursodeoxycholic acid (UDCA), for the treatment of patients with stage 2 to 3 primary biliary cholangitis (PBC) to improve clinical efficacy, symptoms, liver function, and liver fibrosis.

Other names
Bushen Huoxue formulaBushen Huoxue granulesBushen Huoxue recipeTCM tonifying kidney and activating blood granules补肾活血颗粒
02

Targets

EGFR (Epidermal growth factor receptor)NOS2 (Nitric Oxide Synthase 2)NOS3 (eNOS)SRC (Proto-oncogene tyrosine-protein kinase Src)STAT3 (Signal Transducer and Activator of Transcription 3)

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