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traditional Chinese medicine granules for tonifying kidney and promoting blood circulation

Development stage: Preclinical
Lead developer: Longhua Hospital Shanghai University of Traditional Chinese Medicine
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Traditional Chinese medicine granules for tonifying kidney and promoting blood circulation (also known as Bushen Huoxue granules) is an investigational herbal formulation developed by Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. It is designed to address the traditional Chinese medicine (TCM) syndrome pattern of liver-kidney yin deficiency with blood stasis. The formulation is being evaluated in clinical trials in China, in combination with ursodeoxycholic acid (UDCA), for the treatment of patients with stage 2 to 3 primary biliary cholangitis (PBC) to improve clinical efficacy, symptoms, liver function, and liver fibrosis.

Other names: Bushen Huoxue formulaBushen Huoxue granulesBushen Huoxue recipeTCM tonifying kidney and activating blood granules补肾活血颗粒

Targets

NOS3 (eNOS)STAT3 (Signal Transducer and Activator of Transcription 3)NOS2 (Nitric Oxide Synthase 2)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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