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tramadol + diclofenac
- Development stage
- Unknown
- Lead developer
- Grünenthal
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tramadol + diclofenac is a fixed-dose combination analgesic used for the management of moderate to severe pain, including acute musculoskeletal pain, postoperative pain, and acute flares of osteoarthritis or rheumatoid arthritis[1][2][8]. This combination leverages two complementary mechanisms of action for synergistic pain relief. Tramadol is an atypical opioid that acts as a μ-opioid receptor agonist and inhibits the reuptake of serotonin and norepinephrine in the central nervous system, reducing afferent pain signaling and amplifying inhibitory pathways[1]. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX)-1 and COX‑2 enzymes, thereby blocking prostaglandin synthesis responsible for inflammation and nociceptive pain[6]. The combination provides both immediate (from tramadol) and sustained (from diclofenac) analgesia. Clinical studies have shown this fixed-dose combination to be effective with a favorable safety profile compared to other combinations such as tramadol-paracetamol[1][2].
- Brand names
- DurapainDibol SADibolTromaxTralofenDolfreTramavinDolinstaImedolDuradol Plus
- Other names
- Diclofenac+tramadol
02
Targets
MOR (Mu opioid receptor)SERT (Sodium-dependent serotonin transporter)PGHS-1 (Prostaglandin G/H Synthase 1)NET (Norepinephrine Transporter)
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