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tramadol + oxycodone
- Development stage
- Unknown
- Lead developer
- Mayo Clinic
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination analgesic regimen consisting of tramadol and oxycodone, currently being evaluated by the Mayo Clinic in a Phase 4 clinical trial (NCT07153003) for the management of postoperative pain following primary total knee arthroplasty (TKA) or total hip arthroplasty (THA). Tramadol is a synthetic opioid that provides analgesia through mu-opioid receptor agonism and the inhibition of serotonin and norepinephrine reuptake. Oxycodone is a semi-synthetic full mu-opioid receptor agonist. The study investigates whether this multimodal approach can improve pain control and reduce overall postoperative opioid consumption compared to oxycodone monotherapy.
- Other names
- Tramadol and Oxycodone
02
Targets
SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)MOR (Mu opioid receptor)DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)
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