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TraMag
- Development stage
- Unknown
- Lead developer
- Orphinic Scientific
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
TraMag (TM) is an oral small molecule combination therapy developed by Orphinic Scientific, consisting of the opioid analgesic tramadol and magnesium. It is primarily indicated for the treatment of pain, specifically in the context of osteoarthritis. Tramadol acts as a mu-opioid receptor agonist and a serotonin-norepinephrine reuptake inhibitor (SNRI), while the addition of magnesium is intended to potentially enhance analgesic efficacy or mitigate side effects, possibly through NMDA receptor modulation. The product is currently in the certification and market authorization phase, following clinical development for pain management.
- Brand names
- TraMag
- Other names
- tramadol plus magnesium combination
02
Targets
NET (Norepinephrine Transporter)NMDAR (Glutamate receptor ionotropic, NMDA)MOR (Mu opioid receptor)SERT (Sodium-dependent serotonin transporter)
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