Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
tramiprosate
- Development stage
- Phase 4
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tramiprosate is a small molecule glycosaminoglycan (GAG) mimetic and an orally administered aminosulfonate compound structurally similar to taurine. It was developed to target the underlying pathophysiology of Alzheimer's disease by binding to soluble amyloid beta (Aβ42) monomers and inhibiting their aggregation into toxic oligomers and fibrils. This action prevents the formation of amyloid plaques in the brain—a key pathological feature of Alzheimer's disease. Tramiprosate also acts as a GABA-A receptor agonist due to its structural similarity with γ-aminobutyric acid (GABA), and it exhibits anti-inflammatory effects. The drug was primarily developed by Neurochem for Alzheimer's disease but did not achieve regulatory approval after phase 3 trials; it has since been marketed as a dietary supplement under various brand names[2][4][5][7].
- Brand names
- VIVImindActiveMind
- Other names
- 3-aminopropanesulfonic acidhomotaurine
02
Targets
Aβ (Amyloid-beta peptides and aggregates)GABRR (GABA-A receptor subunit rho)GABAA (Gamma-aminobutyric acid receptor)
Beyond the preview
Go deeper on tramiprosate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on tramiprosate.