tranexamic acid

Tranexamic acid is a synthetic analog of the amino acid lysine, functioning as an antifibrinolytic agent. Its primary mechanism of action involves competitively inhibiting the activation of plasminogen to plasmin by binding to lysine-binding sites on plasminogen. This action prevents the breakdown of fibrin clots, thereby stabilizing hemostasis and reducing excessive bleeding. Developed by Japanese researchers Shosuke and Utako Okamoto in 1962, tranexamic acid is widely used to manage and prevent blood loss in various clinical settings, including heavy menstrual bleeding, hemophilia, trauma, surgical procedures, and postpartum hemorrhage. It is also indicated for hereditary angioedema and is being explored for conditions like melasma and hemoptysis. The drug is available in oral, intravenous, and topical formulations.

Brand names

CyklokapronLystedaCyklo-FFemstrualEvana Heavy Period ReliefTrenaxaPauseTrapicTranostatTEXAkindXamicClot-XLTranemicTranlokCeltranz

Other names

氨甲环酸