trans-chalcone

trans-chalcone is a natural small molecule flavonoid and the thermodynamically stable isomer of chalcone, found in various plants. It exhibits a broad spectrum of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and anthelmintic properties. Mechanistically, it acts as a multi-target modulator of several signaling pathways, primarily activating cytoprotective pathways such as Nrf2, SIRT1, and AMPK, while suppressing pro-inflammatory signaling through the inhibition of NF-κB and the NLRP3 inflammasome. Additionally, trans-chalcone has been identified as a pore blocker for large-conductance calcium-activated potassium (BKCa) channels and an antagonist for nociceptive TRP channels (TRPV1 and TRPA1). Research suggests potential therapeutic applications in metabolic diseases like obesity and NAFLD, neurodegenerative conditions such as Parkinson's disease, cardiovascular injuries, and various cancers.

Other names

1,3-diphenyl-2-propen-1-one(E)-chalconeTC