Drug intelligence / Profile preview

TransCon treprostinil

Development stage
Discontinued
Lead developer
Ascendis Pharma
Modality
Small Molecules
Administration
Subcutaneous
01

Overview

TransCon treprostinil is a prodrug formulation of treprostinil being developed for the treatment of pulmonary arterial hypertension (PAH). It utilizes Ascendis Pharma's proprietary TransCon technology platform, which enables sustained release of unmodified treprostinil following once-daily subcutaneous injection. The drug is designed to produce a pharmacokinetic profile comparable to continuously infused prostacyclins while offering a more convenient administration route and avoiding complications associated with infused therapies such as infusion site pain and risk of bloodstream infections.

Other names
Concentrated treprostinil Technosphere
02

Targets

PTGIR (Prostanoid IP Receptor)PTGDR (Prostanoid DP1 receptor)PPARD (Peroxisome proliferator–activated receptor delta)PTGER2 (Prostaglandin E2 receptor EP2)P2Y12 (Purinergic P2Y12 receptor)

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