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transforming growth factor beta 1 mesenchymal stem cell-derived exosomes
- Development stage
- Preclinical
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Transforming growth factor beta 1 (TGF-β1) mesenchymal stem cell-derived exosomes are engineered extracellular vesicles harvested from mesenchymal stem cells (MSCs) that have been genetically modified to overexpress the anti-inflammatory cytokine TGF-β1. These exosomes function as a cell-free therapeutic platform, combining the innate immunomodulatory properties of MSC-derived vesicles with the potent signaling of TGF-β1. In preclinical models of sepsis, these exosomes have demonstrated the ability to protect against systemic inflammation and organ failure by promoting the polarization of macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. This shift in macrophage activity helps resolve the cytokine storm and improve survival outcomes in inflammatory disease states.
- Other names
- TGF-beta 1-modified MSC-derived exosomesTGF-beta1-modified MSC-derived exosomesTGF-beta-1-modified MSC-derived exosomesTGF-beta 1-overexpressing MSC-derived exosomesTGF-beta1-overexpressing MSC-derived exosomesTGF-beta-1-overexpressing MSC-derived exosomesTGF-β1-modified mesenchymal stem cell-derived exosomesTGF-β1-MSC-Exo
02
Targets
TGFBR1
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