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trastuzumab + autologous NK cells
- Development stage
- Unknown
- Lead developer
- Xuzhou Medical University
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Cytokines & Interferons → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
This investigational cellular immunotherapy consists of activated and expanded autologous natural killer (NK) cells administered in combination with the HER2-targeted monoclonal antibody trastuzumab. Developed by Xuzhou Medical University, the therapy involves collecting a patient's own NK cells via apheresis and expanding them ex vivo using a K562 feeder cell line genetically modified to express membrane-bound interleukin-15 (IL-15) and 4-1BB ligand (4-1BBL). The treatment regimen typically includes trastuzumab to target HER2-positive cancer cells and subcutaneous interleukin-2 (IL-2) to support NK cell survival and activity. The primary mechanism of action is the enhancement of antibody-dependent cellular cytotoxicity (ADCC), where the expanded NK cells recognize and destroy trastuzumab-coated tumor cells, specifically for the treatment of HER2-positive advanced gastric cancer.
- Other names
- activated and expanded autologous NK cellsexpanded NK cellsCombination Trastuzumab With Expanded NK Cells
02
Targets
FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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