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trastuzumab deruxtecan + ivonescimab
- Development stage
- Unknown
- Lead developer
- Daiichi Sankyo
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Trastuzumab deruxtecan + ivonescimab is an investigational combination therapy comprising a HER2-directed antibody-drug conjugate (ADC) and a bispecific antibody. Trastuzumab deruxtecan (T-DXd) consists of a humanized anti-HER2 monoclonal antibody linked to a topoisomerase I inhibitor payload (deruxtecan), designed to target and kill HER2-expressing tumor cells. Ivonescimab is a first-in-class bispecific antibody that simultaneously targets programmed cell death protein 1 (PD-1) and vascular endothelial growth factor (VEGF), combining immunotherapy with anti-angiogenesis. This combination is being evaluated in Phase II clinical trials (e.g., the UNITY study) for patients with hormone receptor-positive (HR+), HER2-low or HER2-ultralow advanced breast cancer, including those with central nervous system (CNS) metastases.
- Other names
- Trastuzumab Deruxtecan and ivonescimabT-DXd + ivonescimab
02
Targets
ABCG2 (Breast cancer resistance protein)PDCD1 (Programmed cell death protein 1 receptor)TOP1 (DNA Topoisomerase I)ERBB2 (Erb-b2 receptor tyrosine kinase 2)P-gp (ATP-binding cassette sub-family B member 1)VEGFA (Vascular endothelial growth factor A)SLCO1B3 (Organic anion transporting polypeptide 1B3)CYP3A7 (Cytochrome P450 3A7)
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