Drug intelligence / Profile preview

trazodone

Development stage
Approved
Lead developer
Angelini
Modality
Small Molecules
Administration
Oral
01

Overview

Trazodone is an oral antidepressant medication belonging to the phenylpiperazine class. It is classified as a serotonin antagonist and reuptake inhibitor (SARI). Trazodone is primarily used to treat major depressive disorder and can also be prescribed for anxiety disorders and insomnia. It works by modulating serotonin activity in the brain to help restore mental balance. Due to its sedative effects, it is sometimes used off-label for sleep disturbances. Common side effects include dry mouth, dizziness, vomiting, headache; more serious side effects may include suicidal thoughts or behaviors (especially in young people), mania or hypomania in bipolar disorder patients, irregular heart rate (arrhythmia), and priapism (prolonged erection). The drug was approved for medical use in the United States in 1981[1][2][3].

Brand names
DesyrelDesyrel DividoseOleptroRaldesy
Other names
曲唑酮盐酸曲唑酮
02

Targets

ADRA2A (α2A)5-HT2C (5-hydroxytryptamine receptor 2C)SERT (Sodium-dependent serotonin transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR7 (5-hydroxytryptamine receptor 7)ADRA1A (α1A)

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