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trazodone hydrochloride (new polymer formulation)
- Development stage
- Unknown
- Lead developer
- Angelini Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Trazodone hydrochloride (new polymer formulation) is an extended-release, small molecule antidepressant being developed by Aziende Chimiche Riunite Angelini Francesco S.p.A (Angelini Group) for the treatment of major depressive disorder. This specific product utilizes a novel polymer-based controlled-release technology designed to optimize the pharmacokinetic profile of trazodone, distinguishing it from previous extended-release versions such as the Contramid-based formulation (marketed as Oleptro or Trittico). Trazodone acts as a serotonin antagonist and reuptake inhibitor (SARI), primarily functioning as an antagonist at the 5-HT2A and 5-HT2C receptors and as an inhibitor of the serotonin transporter (SERT). It also exhibits antagonistic activity at alpha-1 adrenergic and histamine H1 receptors, which contributes to its clinical profile. The new polymer formulation is currently undergoing Phase 1 clinical evaluation to establish its bioavailability and bioequivalence relative to existing once-a-day trazodone products.
- Other names
- trazodone hydrochloride (new polymer)trazodone OAD
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)HRH1 (Histamine H1 Receptor)SERT (Sodium-dependent serotonin transporter)ADRA1A (α1A)
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