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Tree MATA MPL
- Development stage
- Phase 2
- Lead developer
- Allergy Therapeutics
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Tree MATA MPL is a pre-seasonal subcutaneous immunotherapy product developed for the treatment of allergic rhinitis and/or rhinoconjunctivitis due to tree pollen hypersensitivity. It contains an extract of multiple tree pollens modified with glutaraldehyde to form allergoids that reduce reactivity with immunoglobulin E (IgE) antibodies while preserving T-cell reactivity. The allergoid is adsorbed onto microcrystalline tyrosine as a depot adjuvant system and includes monophosphoryl lipid-A (MPL) as an adjuvant to enhance the immune response and promote a shift from Th2 to Th1 helper T-cell responses. This formulation aims to induce broad protective immune responses by stimulating IgG4 and IgA antibody production, thereby reducing allergic symptoms[3].
- Brand names
- Pollinex Quattro TreePollinex Quattro
- Other names
- Tree pollen modified allergen tyrosine-adsorbedInjectable MPL allergy vaccineTree pollen allergen extractPQ Tree
02
Targets
TLR4 (Toll-like receptor 4)TCR (T cell antigen receptor complex)
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