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Treg-depleted donor lymphocyte infusion
- Development stage
- Phase 2
- Lead developer
- Assistance publique - Hôpitaux de Paris
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Treg-depleted donor lymphocyte infusion (DLI) is an adoptive cellular immunotherapy developed by Assistance Publique - Hôpitaux de Paris for the treatment of relapsed hematological malignancies following allogeneic hematopoietic stem cell transplantation (HSCT). The therapy involves the infusion of donor lymphocytes from which regulatory T cells (Tregs) have been selectively removed. Tregs are known to suppress anti-tumor immune responses; by depleting them, the graft-versus-leukemia (GVL) effect of the donor T cells is enhanced. While earlier strategies targeted CD25 for depletion, this specific approach utilizes CD127 (interleukin-7 receptor alpha) positive selection to more effectively isolate and remove the Treg population, thereby amplifying the allogeneic immune response against malignant cells.
- Other names
- Regulatory T cell-depleted donor lymphocyte infusionCD127-selected Treg-depleted DLICD-127-selected Treg-depleted DLICD 127-selected Treg-depleted DLI
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