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treprostinil (nebulized)
- Development stage
- Approved
- Lead developer
- United Therapeutics
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
Nebulized Tyvaso is a formulation of **treprostinil**, delivered via inhalation using a dedicated portable nebulizer device. Treprostinil is a prostacyclin mimetic that acts as a vasodilator, primarily used in the treatment of **pulmonary arterial hypertension** (PAH; WHO Group 1) and **pulmonary hypertension associated with interstitial lung disease** (PH-ILD; WHO Group 3). It works by widening the pulmonary blood vessels, reducing vascular resistance, and improving exercise capacity. Clinical trials supporting its approval primarily included patients with NYHA Functional Class III symptoms. The nebulized form allows direct delivery to the lungs with minimal systemic exposure, administered 4 times daily using the Tyvaso Inhalation System[1][3][5].
- Brand names
- TyvasoTyvaso Nebulizer
- Other names
- treprostinil (inhalation solution)treprostinil nebulizer solution
02
Targets
PTGIR (Prostanoid IP Receptor)PTGDR (Prostanoid DP1 receptor)PTGER2 (Prostaglandin E2 receptor EP2)KCNK2 (Potassium channel subfamily K member 2)KCNK10
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