Drug intelligence / Profile preview

Trequilon

Development stage
Unknown
Lead developer
Innapharma
Modality
Small Molecules
Administration
Topical
01

Overview

Trequilon is a topical combination cream containing fluocinolone acetonide (0.01%), hydroquinone (4%), and tretinoin (0.05%). Developed by Innapharma, it is indicated for the short-term treatment of moderate-to-severe melasma of the face. The combination works synergistically: hydroquinone acts as a melanin synthesis inhibitor to lighten hyperpigmented areas; tretinoin, a retinoid, increases skin cell turnover to enhance the penetration of hydroquinone; and fluocinolone acetonide, a mild corticosteroid, reduces local inflammation and irritation associated with the other active ingredients.

Brand names
Trequilon
Other names
fluocinolone acetonide + hydroquinone + tretinoinfluocinolone acetonide, hydroquinone, and tretinoinfluocinolone/hydroquinone/tretinoin
02

Targets

GR (Glucocorticoid receptor)RARA (Retinoic acid receptor alpha)RARB (Retinoic acid receptor beta)RARG (Retinoic acid receptor gamma)TYR (Tyrosinase)

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