Drug intelligence / Profile preview

TresMonet

Development stage
Unknown
Lead developer
TresMonet
Modality
Small Molecules
Administration
Topical
01

Overview

TresMonet is a topical triple-combination therapy indicated for the short-term treatment of moderate-to-severe melasma of the face. It combines three active ingredients: hydroquinone, a skin-bleaching agent; tretinoin, a retinoid that increases skin cell turnover; and mometasone furoate, a medium-potency corticosteroid that reduces inflammation. Hydroquinone works by inhibiting the enzyme tyrosinase, thereby preventing the synthesis of melanin. Tretinoin promotes the shedding of melanin-containing keratinocytes and enhances the penetration of hydroquinone. Mometasone furoate serves to mitigate the irritation and inflammation often caused by the other two components. This synergistic approach is designed to provide more effective depigmentation than any of the components used individually.

Brand names
TresMonet
Other names
Hydroquinone + Tretinoin + Mometasone Furoate
02

Targets

NR superfamily (Nuclear receptor superfamily)TYR (Tyrosinase)GR (Glucocorticoid receptor)

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