Drug intelligence / Profile preview

Tret-A

Development stage
Preclinical
Lead developer
Derm Avance
Modality
Small Molecules
Administration
Topical
01

Overview

Tret-A is a topical retinoic acid precursor lotion developed by DermAvance. It is designed to be applied to the skin, where it undergoes enzymatic conversion into retinoic acid (tretinoin), the active metabolite of Vitamin A. This metabolic conversion is intended to provide the therapeutic benefits of retinoids, such as the regulation of epithelial cell growth and differentiation, while potentially mitigating the skin irritation and erythema often associated with the direct application of tretinoin. The product is positioned within DermAvance's pipeline for dermatological indications, likely targeting conditions such as acne vulgaris or photoaging.

Brand names
Tret-A
Other names
retinoic acid precursor lotion
02

Targets

RARB (Retinoic acid receptor beta)RARA (Retinoic acid receptor alpha)RXRG (RXRγ)RARG (Retinoic acid receptor gamma)RXRB (Retinoid X receptor beta)RXRA (Retinoid X receptor alpha)CRBP1 (Retinol-binding protein 1 (Cellular retinol-binding protein I))

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