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TreXTAM
- Development stage
- Preclinical
- Lead developer
- TherapyX
- Modality
- Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
TreXTAM is a microparticulate therapeutic candidate developed by TherapyX for the treatment of autoimmune diseases. Currently in the IND-enabling stage, TreXTAM is based on the company's TreX platform, which focuses on the induction and expansion of regulatory T cells (Tregs) to restore immune tolerance. The formulation utilizes TherapyX's proprietary microparticle technology—typically composed of poly(lactic-co-glycolic acid) (PLGA)—to deliver a combination of Treg-promoting cytokines, such as Transforming growth factor beta (TGF-beta) and Interleukin-2 (IL-2), alongside specific autoantigens (Targeted Antigenic Microparticles or TAM). This site-specific, controlled-release approach is designed to suppress pathogenic immune responses while avoiding the systemic toxicity associated with high-dose cytokine therapy.
- Other names
- TreX-TAM
02
Targets
RARA (Retinoic acid receptor alpha)TGFBR (TGF-beta receptor)IL-2R (Interleukin-2/interleukin-15 receptor complex)
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