triacsin c

Triacsin C is a small molecule natural product originally isolated from the actinobacterium Streptomyces aureofaciens. It acts as a potent and specific inhibitor of long-chain fatty acyl-CoA synthetases (ACSLs), enzymes that catalyze the conversion of free long-chain fatty acids into their CoA derivatives. By inhibiting ACSLs, Triacsin C blocks the de novo synthesis of triglycerides, diglycerides, cholesterol esters, and phospholipids—key steps in lipid metabolism[5][9][6]. This leads to interference with lipid droplet formation and has downstream effects such as inhibition of β-cell apoptosis (lipoapoptosis), vasodilation via increased nitric oxide synthesis and eNOS activity[5][3], anti-proliferative effects on certain cell types[4], and anti-atherosclerotic activity[8]. Triacsin C is used primarily as a research tool in studies involving lipid metabolism, apoptosis regulation, cardiovascular biology (vasodilation), metabolic disease models including obesity and diabetes-related β-cell dysfunction[5], cancer research[10], and viral assembly studies.

Other names

(3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane1-Hydroxy-3-(2',4',7'-undecatrienylidine)triazene