triamcinolone

Triamcinolone is a synthetic corticosteroid (glucocorticoid) used to treat a wide range of inflammatory and autoimmune conditions. It acts primarily by binding to the glucocorticoid receptor and altering gene transcription to suppress inflammation and immune responses[6][8]. Triamcinolone inhibits phospholipase A2 activity on cell membranes, preventing the release of arachidonic acid and subsequent synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes[8]. It also reduces vascular dilation and permeability while inhibiting nuclear factor kappa-B-mediated production of cytokines like interleukin-6. Triamcinolone is available in multiple formulations (oral, topical, intramuscular injection) for indications including allergic disorders (e.g., asthma), dermatologic diseases (e.g., eczema), arthritis (rheumatoid arthritis/osteoarthritis), ulcerative colitis, lupus erythematosus, various eye diseases (including macular edema associated with uveitis), respiratory disorders, certain cancers as adjunct therapy, among others[3][4][5][8]. The drug was first approved by the FDA in 1957[8].

Brand names

AristocortKenalogNasacortTridermVolon A

Other names

triamcinolonetriamcinolone acetonidetriamcinolone diacetatetriamcinolone hexacetonide