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triamcinolone + hyaluronic acid + dextrose
- Development stage
- Unknown
- Lead developer
- Taipei Medical University
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
This investigational combination therapy consists of triamcinolone (a corticosteroid), hyaluronic acid (a viscosupplement), and dextrose (a hypertonic sugar solution), administered via ultrasound-guided intra-articular injection. Developed by researchers at Taipei Medical University, the regimen is designed to treat knee osteoarthritis by simultaneously addressing joint inflammation, restoring synovial fluid viscosity, and stimulating connective tissue repair through prolotherapy. Triamcinolone acts as a glucocorticoid receptor agonist to reduce inflammation, hyaluronic acid provides mechanical lubrication and shock absorption, and dextrose acts as an irritant to trigger a localized healing response in the joint's connective tissues.
- Other names
- steroid + hyaluronic acid + dextrosetriamcinolone acetonide + hyaluronic acid + dextrose
02
Targets
GR (Glucocorticoid receptor)CD44 (CD44 antigen)RHAMM (Hyaluronan-mediated motility receptor)MR (Mineralocorticoid receptor)
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