Drug intelligence / Profile preview

triamcinolone acetonide + curcumin

Development stage
Unknown
Modality
Small Molecules
Administration
Topical
01

Overview

A combination therapy consisting of triamcinolone acetonide (a synthetic corticosteroid) and curcumin (a natural polyphenol derived from turmeric). This combination is primarily used for treating oral lichen planus (OLP), particularly erosive and ulcerative forms. The combination has demonstrated superior efficacy compared to triamcinolone acetonide alone in reducing symptoms, decreasing lesion size, and improving inflammatory markers. Triamcinolone acetonide provides anti-inflammatory effects through corticosteroid action, while curcumin contributes antioxidant, anti-inflammatory, and antifungal properties that may help prevent complications associated with corticosteroid use.

02

Targets

GR (Glucocorticoid receptor)NF-κB

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