Drug intelligence / Profile preview

triamcinolone acetonide + povidone-iodine + lidocaine hydrochloride + bupivacaine

Development stage
Unknown
Modality
Small Molecules
Administration
Epidural, Intraarticular, Intramuscular, Percutaneous, Topical
01

Overview

**Triamcinolone acetonide + povidone-iodine + lidocaine hydrochloride + bupivacaine** is a multi-component procedural kit containing a depot synthetic glucocorticoid, two amide local anesthetics, and a topical antiseptic. Triamcinolone acetonide activates glucocorticoid receptors to suppress inflammatory signaling; lidocaine and bupivacaine inhibit voltage-gated sodium-channel-dependent nerve conduction to provide local or regional anesthesia and analgesia; and povidone-iodine provides local antimicrobial antisepsis. The exact four-component presentation is listed in DailyMed as **MLK F4 Kit**; related P-Care kit presentations package these agents with ancillary sodium chloride and isopropyl-alcohol products. MLK F4 Kit is listed as an unapproved drug other product in FDA NDC-derived labeling, so the combination itself should not be interpreted as an FDA-approved fixed-dose medicine. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=829e3bd1-fb1c-4613-9db3-9a89ef8e2c0c))

Brand names
MLK F4 KitP-Care K40MXP-Care K80MX
Other names
bupivacaine hydrochloride + lidocaine hydrochloride + povidine iodine + triamcinolone acetonidebupivacaine hydrochloride + lidocaine hydrochloride + povidone-iodine + triamcinolone acetonidetriamcinolone acetonide + bupivacaine hydrochloride + lidocaine hydrochloride + povidone iodinetriamcinolone acetonide + lidocaine hydrochloride + bupivacaine hydrochloride + povidine iodine
02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)

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