Drug intelligence / Profile preview

triamcinolone acetonide acetate + econazole nitrate

Development stage
Unknown
Lead developer
Yangtze River Pharmaceutical Group
Modality
Small Molecules
Administration
Topical
01

Overview

Fuyanning Cream (brand name Fu Yan Ning) is a topical combination pharmaceutical product developed and manufactured by Yangzijiang Pharmaceutical Group (Jiangsu Pharmaceutical). It contains two active ingredients: triamcinolone acetonide acetate, a medium-strength corticosteroid, and econazole nitrate, a broad-spectrum imidazole antifungal agent. The formulation is indicated for the treatment of inflammatory skin conditions complicated by fungal infections, including dermatitis, eczema, and various types of tinea (such as tinea pedis, tinea corporis, and tinea cruris). It is also used for diaper dermatitis, paronychia, and mixed bacterial-fungal skin infections. Triamcinolone provides anti-inflammatory, antipruritic, and antiallergic effects by binding to the glucocorticoid receptor and inhibiting the release of inflammatory mediators, while econazole acts by disrupting fungal cell membrane permeability through the inhibition of ergosterol synthesis via the lanosterol 14-alpha demethylase enzyme.

Brand names
Fu Yan Ning扶严宁Fuyanning Cream
Other names
Triamcinolone Acetonide Acetate and Econazole Nitrate Cream醋酸曲安奈德益康唑乳膏
02

Targets

CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)

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