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triamcinolone acetonide preservative-free
- Development stage
- Preclinical
- Lead developer
- Harrow
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Intravitreal (ocular Injection)
01
Overview
TAC-PF refers to a preservative-free formulation of triamcinolone acetonide, a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. In ophthalmology, TAC-PF is formulated for intravitreal injection to treat various retinal diseases such as macular edema and uveitis. The preservative-free aspect is designed to reduce the risk of toxicity or adverse reactions associated with preservatives in ocular tissues. Triamcinolone acetonide acts by inhibiting multiple inflammatory cytokines and suppressing leukocyte infiltration at sites of inflammation, thereby reducing edema, fibrin deposition, capillary dilation, and migration of inflammatory cells[4].
- Other names
- TAC-PF
02
Targets
GR (Glucocorticoid receptor)
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