Drug intelligence / Profile preview

triamcinolone hexacetonide

Development stage
Approved
Lead developer
Pfizer
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intraarticular, Intralesional, Soft Tissue Injection, Intramuscular (less Common)
01

Overview

Triamcinolone hexacetonide is a synthetic glucocorticoid corticosteroid used primarily for its potent anti-inflammatory and immunosuppressive effects. It is a long-acting derivative of triamcinolone, formulated as an injectable suspension for intra-articular, intralesional, or soft tissue administration. The drug works by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability, thereby reducing inflammation and immune responses in various tissues. Triamcinolone hexacetonide is indicated for the treatment of inflammatory joint disorders such as rheumatoid arthritis, psoriatic arthritis, osteoarthritis (especially knee and shoulder), acute gouty arthritis, bursitis, tenosynovitis, epicondylitis; as well as dermatologic conditions like alopecia areata, discoid lupus erythematosus, keloids, granuloma annulare lesions, lichen planus/lichen simplex chronicus (neurodermatitis), psoriatic plaques; necrobiosis lipoidica diabeticorum; and cystic tumors such as ganglia[1][5][6]. Its slow absorption from injection sites provides prolonged local action.

Brand names
AristospanLederspan
Other names
triamcinolone hexacetonideTH
02

Targets

GR (Glucocorticoid receptor)

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