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TRIBIK

Development stage: Phase 3
Lead developer: Biken
Modality: Vaccines & Immunotherapeutics
Administration: Subcutaneous

Overview

**TRIBIK** is an adsorbed, acellular diphtheria-tetanus-pertussis vaccine developed as BK1301. It combines purified *Bordetella pertussis* protective antigens with formalin-detoxified diphtheria and tetanus toxoids, adsorbed onto an aluminum salt, to induce active immunity against pertussis, diphtheria, and tetanus. It is manufactured by BIKEN and marketed in Japan by Tanabe Pharma as a 0.5 mL suspension for subcutaneous injection; it was approved in Japan in 2006 and has been evaluated as an adolescent booster. ([biken.or.jp](https://www.biken.or.jp/upload/product/document_pdf/tribik/interviewform.pdf))

Brand names: TRIBIK
Other names: Adsorbed Diphtheria-purified Pertussis-tetanus Combined VaccineDTaP vaccine沈降精製百日せきジフテリア破傷風混合ワクチン

Targets

TT-BCR (Tetanus toxoid-specific B-cell receptor)TCR (T cell antigen receptor complex)BCR-DT (B-cell receptor specific for diphtheria toxoid)B-cell receptors specific for acellular pertussis antigens

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