Drug intelligence / Profile preview

tribulus saponins

Development stage
Unknown
Lead developer
Changbai Shan Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

tribulus saponins (marketed as Tribulus Saponins Capsules / 蒺藜皂苷胶囊) is a botanical extract derived from the traditional Chinese medicinal herb *Tribulus terrestris* (puncture vine). Developed by Changbai Shan Pharmaceutical, it is approved in China for the treatment of patients in the recovery period of cerebral infarction (stroke) with the traditional Chinese medicine (TCM) syndrome pattern of wind-phlegm-blood stasis obstruction. The drug exhibits anti-platelet aggregation, anti-coagulation, and anti-ischemic properties, helping to reduce cerebral infarct size, lower blood viscosity, and improve microcirculation. It is also widely studied as a dietary supplement for its potential to support male vitality, libido, and athletic performance, although its primary pharmaceutical indication is cerebrovascular recovery.

Other names
Tribulus saponins capsuleTribulus terrestris saponins蒺藜皂苷蒺藜皂苷胶囊
02

Targets

Sucrase-IsomaltaseNF-κBSIRT1 (NAD-dependent protein deacetylase sirtuin-1)AMY (Pancreatic alpha-amylase)HSD11B1 (11-beta-hydroxysteroid dehydrogenase type 1)AR (Adrenergic receptors)

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