triclosan + fluoride + Cavistat

**triclosan + fluoride + Cavistat** is a combination oral care formulation intended for use in dentifrices (toothpastes) to prevent dental caries and promote overall oral health. \n- **Triclosan** is an antimicrobial agent that inhibits bacterial growth, particularly targeting the enoyl-acyl carrier protein reductase enzyme (ENR) in bacteria to suppress fatty acid synthesis, leading to cell death and reduced dental plaque and gingivitis[4][5]. \n- **Fluoride** is well-established for its role in remineralizing tooth enamel and preventing dental caries through inhibition of demineralization and enhancement of remineralization in tooth surfaces[6]. \n- **Cavistat** is less well-documented but is referenced in clinical trials as part of an anti-caries dentifrice formulation, possibly acting as a calcium phosphate delivery agent or remineralization component (such as a complex like arginine-based or CPP-ACP analog), though precise mechanism is not specified in available sources[2]. \nClinical studies show that combinations similar to triclosan + fluoride + copolymer formulations significantly reduce supragingival calculus formation and prevent caries and gingivitis when applied topically via toothpastes[1][3][5].

Other names

triclosan + fluoride + Cavistat