Drug intelligence / Profile preview

triclosan + fluoride + cetylpyridinium chloride

Development stage
Unknown
Modality
Small Molecules
Administration
Topical, Buccal, Dental
01

Overview

This is a **combination oral care formulation** typically found in **toothpastes** or **mouthwashes**, designed for the prevention of dental plaque, gingivitis, and improvement of oral hygiene. The three active substances are: - **Triclosan**: a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis by blocking the enoyl-acyl carrier protein reductase. - **Fluoride**: commonly included as sodium fluoride or sodium monofluorophosphate, it promotes enamel remineralization and inhibits dental caries by enhancing resistance to acid dissolution and reducing demineralization. - **Cetylpyridinium chloride (CPC)**: a quaternary ammonium compound with antiseptic and surfactant properties that disrupts microbial cell membranes, leading to cell death and decreased dental plaque formation. This combination is used in OTC oral hygiene products for **plaque reduction, cavity prevention, and antibacterial action**. Studies support that combinations including triclosan, fluoride, and CPC provide better control of supragingival dental plaque than fluoride alone[1][2]. No specific unique brand or code name was associated directly with this exact three-drug combination, but this profile matches some enhanced oral care formulations in clinical literature.

02

Targets

InhA

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