Drug intelligence / Profile preview

tricyclazole

Development stage
Unknown
Modality
Small Molecules
Administration
Foliar (spray Application To Crops)
01

Overview

Tricyclazole is a systemic fungicide primarily used for the control of rice blast disease caused by Pyricularia oryzae. It acts as a melanin biosynthesis inhibitor by specifically inhibiting melanization within the appressorium of the fungus. This inhibition prevents proper formation and rigidity of the appressorial wall required for fungal penetration into plant tissue. As a result, tricyclazole protects plants from infection but does not cure existing infections; its activity is protective rather than curative. The compound has no significant effect on spore germination but reduces sporulation and can influence pathogenicity in other fungi by damaging cell structures and reducing melanin production. There are also reports that tricyclazole may have adverse effects on mammalian reproductive systems in animal studies[1][2][6].

Brand names
BlascideSivicBEABlas-T
Other names
5-methyl-1,2,4-triazolo[3,4-b]benzothiazole1,2,4-Triazolo[3,4-b]benzothiazole, 5-methyl-s-Triazolo(3,4-b)benzothiazole, 5-methyl-TricyclazolTricyclozole
02

Targets

SD (Scytalone dehydratase)THNR (1,3,8-Trihydroxynaphthalene reductase)

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