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tridihexethyl
- Development stage
- Discontinued
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular, Intravenous
01
Overview
Tridihexethyl is a synthetic anticholinergic and antimuscarinic small molecule drug that was primarily used as its chloride salt. It acts as an antagonist at muscarinic acetylcholine receptors (M1, M2, and M3 subtypes), thereby inhibiting the action of acetylcholine on these receptors. This results in pronounced antispasmodic and antisecretory effects on the gastrointestinal tract by reducing vagally mediated reflexes and gastric acid secretion. Tridihexethyl was indicated as an adjunct in the treatment of peptic ulcer disease and has also been studied for acquired nystagmus. The drug is no longer available in the US market due to side effects and limited use[1][2][3][4][6].
- Brand names
- PathilonPropethonum
- Other names
- tridihexethyl chloridetridihexethyl (chloride)
02
Targets
M1 (Muscarinic acetylcholine receptor M1)CHRM3 (M3)CHRM2 (M2)
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