tridolgosir

Tridolgosir is a natural indolizidine alkaloid also known as swainsonine. It is a potent and reversible inhibitor of Golgi alpha-mannosidase II and lysosomal alpha-mannosidases. By inhibiting these enzymes involved in N-linked glycosylation of glycoproteins in the Golgi apparatus and lysosomes, tridolgosir disrupts the formation of complex carbohydrate structures on cell surfaces. This leads to reduced tumor cell aggressiveness and metastatic potential by decreasing highly branched carbohydrates that bind to lectin-phytohemagglutinin (L-PHA), while increasing “hybrid type” carbohydrates that may enhance immune recognition by lymphocytes and natural killer cells. Tridolgosir has demonstrated antiproliferative and immunomodulatory effects in preclinical studies but did not show anti-tumor activity in phase II clinical trials for renal cell carcinoma. It is also recognized as a plant toxin responsible for locoweed poisoning in livestock[1][2][3][4][5][6][7].

Brand names

tridolgosir

Other names

swainsonineswainsonine hydrochloridetridolgosir hydrochloride(1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol