triestrogen

Triestrogen is a bioidentical hormone replacement therapy (BHRT) formulation consisting of three naturally occurring estrogens: estriol (E3), estradiol (E2), and estrone (E1). It is typically prepared by compounding pharmacies in a specific ratio, most commonly 80% estriol, 10% estradiol, and 10% estrone, designed to mimic the physiological estrogen profile of premenopausal women. While primarily utilized to manage vasomotor symptoms and other complications of menopause, clinical research has also explored its use as part of a multi-component hormonorestorative therapy to treat steroidopenia-associated hypercholesterolemia. By restoring youthful levels of steroid hormones, triestrogen helps maintain cholesterol homeostasis and normalize lipid profiles. As a compounded product, it is not a single proprietary drug developed by a specific pharmaceutical company but is widely used in individualized hormone therapy.

Brand names

Tri-estTriestrogen

Other names

Tri-estrogen3-estrogen combinationEstriol + Estradiol + Estrone