trifarotol

Trifarotol is a 4th-generation retinoid developed by Actera for cosmetic applications, specifically targeting skin aging and rejuvenation. It is the alcohol derivative of trifarotene, a highly selective retinoic acid receptor gamma (RAR-gamma) agonist. RAR-gamma is the most abundant retinoic acid receptor in the epidermis, and its activation regulates key processes such as keratinocyte differentiation, epidermal proliferation, and collagen synthesis. Trifarotol is designed to provide the potent biological effects of 4th-generation retinoids—such as improved skin texture and reduced fine lines—within the regulatory framework of cosmetic ingredients, potentially offering enhanced stability or reduced irritation compared to traditional retinoids like retinol or tretinoin.

Brand names

Trifarotol