trifluoro-thiamin phosphate

Trifluoro-thiamin phosphate is a synthetic thiamine (vitamin B1) analog in which the methyl group at the 2-position of the pyrimidine ring is replaced by a trifluoromethyl group. It belongs to the class of thiamine phosphates and has been studied primarily as an experimental compound. Trifluoro-thiamin phosphate acts as an inhibitor or poor substrate for thiamin phosphate synthase, an enzyme involved in thiamine biosynthesis. This property makes it useful for probing enzyme mechanisms and as a potential lead compound for antimicrobial drug development targeting bacterial thiamine biosynthesis pathways, such as those in Mycobacterium tuberculosis[1][2][9]. The compound is not approved for clinical use and remains at the experimental stage.

Other names

3-((4-amino-2-(trifluoromethyl)pyrimidin-5-yl)methyl)-4-methyl-5-(2-(phosphonatooxy)ethyl)-1,3-thiazol-3-ium3-{[4-amino-2-(trifluoromethyl)pyrimidin-5-yl]methyl}-4-methyl-5-[2-(phosphonatooxy)ethyl]-1,3-thiazol-3-iumZIBIECXVPMYJCV-UHFFFAOYSA-MTRIFLUORO‐THIAMIN PHOSPHATE